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KMID : 0545120080180020369
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Journal of Microbiology and Biotechnology
2008 Volume.18 No. 2 p.369 ~ p.376
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Radioprotective Effect of Cyclo(L-Phenylalanyl-L-Prolyl) on Irradiated Rat Lung
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Lee Keyong-Ho
Rhee Ki-Hyeong
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Abstract
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In the present study, we investigated the radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lungs to determine its potential as a radioprotective agent. We found that early lung damage induced by irradiation was reduced by treatment with 40 mg/kg of cyclo(Lphenylalanyl- L-prolyl) in the latent and early pneumonitis phases. Expression of TNF-α and TGF-β1 at 2 and TGF-β1 at 8 weeks post-irradiation was decreased in animals that received both radiation and cyclo(L-phenylalanyl-L-prolyl) compared with animals that received radiation alone. Evidence indicated that the proinflammatory cytokine TNF-α and the fibrogenic cytokine TGF-β1 likely play a role in the radioprotective effect of cyclo(L-phenylalanyl-L-prolyl). However, besides TNF-α and TGF-β1 expressions, the precise mechanism by which cyclo(L-phenylalanyl-L-prolyl) ameliorates the induced radiation damage is not clear.
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KEYWORD
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Cyclo(L-phenylalanyl-L-prolyl), radioprotective agent, TNF-α, TGF-β1
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